The Herbert and Florence Irving Institute for Cancer Dynamics will continue its seminar series on the topic of mathematical sciences underpinning cancer research during the 2022-2023 academic year. The monthly seminars take place on the second Wednesday of the month, 2:00-3:00 PM EST. The presentations are open to the Columbia community (in person and online) and to researchers outside Columbia (via Zoom).
On Wednesday, March 13th (2:00 PM ET), IICD welcomes Brittany Adamson, Assistant Professor of Molecular Biology and Lewis-Sigler Institute for Integrative Genomics at Princeton University. Seminar hosted by José McFaline-Figueroa. The seminar will take place in person in Fairchild 700 (Morningside Heights campus). If you wish to attend the seminar remotely, please register using the following link: https://columbiauniversity.zoom.us/meeting/register/tJYsd-urpjgiG9b1sk_B4764Ct3JrqG3-j87
Title: Mapping the Cellular Determinants of Genome Editing in Human Cells
Abstract: Efforts to repurpose CRISPR-Cas systems have produced a suite of genome editing tools, including programmable nucleases, base editors, and prime editors. These tools have greatly enabled the study of genomes and gene function, and their advancement to therapeutic development has demonstrated promise for addressing a host of unmet medical needs. Our understanding of how endogenous cellular processes influence the activity of these tools, however, lags far behind their application and, due to the rapid pace of technology development, behind efforts to build new approaches. Our work focuses on identifying cellular determinants of genome editing tools to better understand how they work. Our results provide key insights into how those tools interact with the cellular environment and suggest general strategies for improvement.
Bio: Dr. Adamson is an assistant professor in the Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics at Princeton University. She is also a member of the Genomic Instability and Cancer Genetics Program at the Rutgers Cancer Institute of New Jersey. Dr. Adamson started her training in 2004 at the Massachusetts Institute of Technology in the laboratory of Angelika Amon. In 2007, she joined the lab of Stephen Elledge at Harvard Medical School, where she used functional genomics approaches to study DNA repair in human cells. She earned her PhD from Harvard Medical School in 2012. Dr. Adamson then worked with Jonathan Weissman at the University of California, San Francisco, where she received a postdoctoral fellowship from the Damon Runyon Cancer Research Foundation. Her postdoctoral work pioneered new approaches for functional genomics in human cells, technologies that now enable dissection of cellular pathways with unprecedented resolution. With her lab at Princeton, Dr. Adamson continues to use and develop cutting-edge experimental tools, including genetic screening methods and single-cell RNA- sequencing, to study genome editing and DNA repair, as well as other areas of interest to the group. Dr. Adamson is the recipient of a 2020 Searle Scholars Award and Rutgers Cancer Institute of New Jersey New investigator Award. Publications: https://scholar.google.com/citations?user=YUSIVGQAAAAJ&hl=en&oi=ao
If you would like to meet one-on-one (possibility via zoom) or attend the lunch or dinner with the speaker, please contact the event organizer.
