IICD Newsletter April 7, 2025

April 07, 2025
IICD Newsletter April 7, 2025  🔬
April 7, 2025
 

Bridging Biology and Biomechanics: The Dumitrascu Lab’s New Computational Framework Illuminates Tissue Development

An overview of the spatial mechano-transcriptomics pipeline (Dumitrascu Lab)

Dr. Bianca Dumitrascu’s lab published a new study in Nature Methods introducing a computational pipeline that integrates spatial transcriptomics with mechanical force inference. This novel approach provides new insights into how physical forces shape tissue development. 

Read More

Meet the 2025 Alliance Interns Joining IICD This Spring

Clockwise, from top right, Sara El Baghdadi, Ethan Cohen, Tudy Herriou, Léandre Simon, and Mathias Perez

The IICD is pleased to welcome five talented students as part of the 2025 Alliance Program, an initiative that provides master’s students from the École Polytechnique the opportunity to contribute to cutting-edge research at Columbia University. From March through August, these interns will collaborate with IICD faculty and researchers on projects ranging from stochastic modeling to machine learning applications in cancer research.

Read More

IICD Seminar Series: April Seminar

Jean Fan, PhD

Multi-Sample Comparative Spatial Omics Data Analysis

Hosted by: Jellert Gaublomme, PhD
Date: April 9, 2025 
Time: 2:00 PM (ET)
Location: Schermerhorn Hall 603 and via Zoom

 
Register Here

IICD Highlights

Calling grad students & postdocs! Join our FREE 5-day workshop (June 23-27, 2025): Methods in Single-Cell Data Integration & Optimal Transport Plus, attend our virtual bootcamp on June 20 to brush up on key concepts! The deadline to apply is April 17th. 

Apply Here
We’re excited to announce that IICD is now on Bluesky! Follow us at @cancerdynamics.bsky.social to stay up to date on the latest research highlights, news, and events from across our community. Come connect with us—we’d love to see you there!

 
Elham Azizi headshot
The Vilcek Foundation recently featured Dr. Elham Azizi’s pioneering work in computational biology, highlighting her research on modeling immune responses and cancer treatment strategies, as well as her advocacy for equity and inclusion in STEM. Read here.

 
Maithê Rocha Monteiro de Barros speaking at NIH meeting
Dr. Maithê R. M. de Barros discussed “The Healthy Stomach in Mice: Insights from Single-Nuclei RNA and ATAC Sequencing” at the NIH Program on the Origins of Gastroesophageal Cancers Annual Meeting at Columbia, highlighting her work with Drs. Karol Nowicki-Osuch and Simon Tavaré.
 
Khanh Dinh headshot
Dr. Khanh Dinh is a co-I on a newly awarded NMRC Open Fund - Young Individual Research Grant led by Dr. Alvin Ng (NTU Singapore). The project will explore ecDNA modeling and cancer copy number dynamics using mathematical frameworks developed by Dinh’s team.

 
Jiacheng Gu
Congratulations to Jiacheng Gu, PhD student in the Gaublomme Lab, for receiving the Trainee Associate Membership Paper of the Year Award! Jiacheng's paper, "Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap," exemplifies outstanding research in the field.
 
Cécile Liu
Welcome to Cécile Liu, who joins IICD as a Visiting Student Intern in the Tavaré Lab! Cécile is currently pursuing an MS in Mathematics, Vision, and Learning at ENS Paris-Saclay. Her research focuses on using Approximate Bayesian Computation to model cell population dynamics in cancer and stem cell biology. 
 

Recent Publications from IICD Researchers

Birth and Death Processes in Phylogenetics and Population Genetics. Tavaré, S. Phil. Trans. R. Soc. B 2025 380:20230300.

Caspase 3 and Caspase 7 Promote Cytoprotective Autophagy and the DNA Damage Response during Non-Lethal Stress Conditions in Human Breast Cancer Cells. Samarasekera, G.; Go, N. E.; Choutka, C.; Xu, J.; Takemon, Y.; Chan, J.; Chan, M.; Perera, S.; Aparicio, S.; Morin, G. B.; Marra, M. A.; Chittaranjan, S.; Gorski, S. M. PLoS biology 2025, 23 (2), e3003034.

Geospatially Informed Representation of Spatial Genomics Data with SpatialFeatureExperiment. Moses, L.; Huseynov, A.; Rich, J. M.; Pachter, L. bioRxiv 2025.

Hepatic Stellate Cells Control Liver Zonation, Size and Functions via R-spondin 3. Sugimoto, A.; Saito, Y.; Wang, G.; Sun, Q.; Yin, C.; Lee, K. H.; Geng, Y.; Rajbhandari, P.; Hernandez, C.; Steffani, M.; Qie, J.; Savage, T.; Goyal, D. M.; Ray, K. C.; Neelakantan, T. V.; Yin, D.; Melms, J.; Lehrich, B. M.; Yasaka, T. M.; Liu, S.; Oertel, M.; Lan, T.; Guillot, A.; Peiseler, M.; Filliol, A.; Kanzaki, H.; Fujiwara, N.; Ravi, S.; Izar, B.; Brosch, M.; Hampe, J.; Remotti, H.; Argemi, J.; Sun, Z.; Kendall, T. J.; Hoshida, Y.; Tacke, F.; Fallowfield, J. A.; Blockley-Powell, S. K.; Haeusler, R. A.; Steinman, J. B.; Pajvani, U. B.; Monga, S. P.; Bataller, R.; Masoodi, M.; Arpaia, N.; Lee, Y. A.; Stockwell, B. R.; Augustin, H. G.; Schwabe, R. F. Nature 2025.

Hierarchical Refinement: Optimal Transport to Infinity and Beyond. Halmos, P.; Gold, J.; Liu, X.; Raphael, B. J. arXiv 2025.

Inferring Active Mutational Processes in Cancer using Single-Cell Sequencing and Evolutionary Constraints. Satas, G.; Myers, M. A.; McPherson, A.; Shah, S. P. bioRxiv 2025.

Joint Imputation and Deconvolution of Gene Expression across Spatial Transcriptomics Platforms. Zheng, H.; Sarkar, H.; Raphael, B. J. bioRxiv 2025.

Resolving Discrepancies between Chimeric and Multiplicative Measures of Higher-Order Epistasis. Chitra, U.; Arnold, B.; Raphael, B. J. Nature Communications 2025, 16 (1), 1711.

The Tree Labeling Polytope: A Unified Approach to Ancestral Reconstruction Problems. Schmidt, H.; Raphael, B. J. bioRxiv 2025.

Transcriptomic Plasticity is a Hallmark of Metastatic Pancreatic Cancer. Jimenez-Sanchez, A.; Persad, S.; Hayashi, A.; Umeda, S.; Sharma, R.; Xie, Y.; Mehta, A.; Park, W.; Masilionis, I.; Chu, T.; Zhu, F.; Hong, J.; Chaligne, R.; O'Reilly, E. M.; Mazutis, L.; Nawy, T.; Pe'er, I.; Iacobuzio-Donahue, C. A.; Pe'er, D. bioRxiv 2025

Stay Connected with Us
Twitter
Instagram
LinkedIn
YouTube
Email
Website
IICD Events Calendar
Get the News Every Month: Subscribe
Copyright © 2025 IICD, All rights reserved.
You are receiving this email because you opted in via our website.

Our mailing address is:
IICD
Schermerhorn Hall, 1190 Amsterdam Ave
New York, NY 10027

Add us to your address book


Want to change how you receive these emails?
You can update your preferences or unsubscribe from this list.