Elana Fertig, PhD
Director of the Institute for Genome Sciences
Associate Director of Quantitative Sciences, UM Greenebaum Comprehensive Cancer Center
Dean E Albert Reece Endowed Professor of Medicine and Professor of Epidemiology (secondary)
University of Maryland School of Medicine
Title: "Forecasting Carcinogenesis"
Description: This talk presents a hybrid computational and experimental strategy to uncover interactions between neoplastic cells and the microenvironment during pancreatic carcinogenesis and immunotherapy response. Pancreatic cancers are notoriously immunosuppressive, with immunosuppression developing with the cancer and requiring combination treatment strategies to sensitize their microenvironment to immune checkpoint inhibitors at the late stage at which they are diagnosed. New single-cell and spatial molecular profiling technologies enable unprecedented characterization of the cellular and molecular composition of the microenvironment. These technologies provide the potential to identify signaling between immune cells, including immune aggregates, and the microenvironment. Further combining these data-driven spatial multi-omics analyses with first-principles, mechanistic mathematical modeling provides a forecast system that can yield computational predictions to model emergent cell behaviors and response to therapeutic selection. This mathematical forecast system will empower a new predictive oncology paradigm, leveraging computational systems to predict the impact of tumor-TME interactions.
Join Zoom Meeting
https://columbiacuimc.zoom.us/j/93269055670?pwd=RiA2n0N1EjW9B3GeaifF461bdbOLdE.1
Meeting ID: 932 6905 5670
Passcode: 546000
