Emily M. Mace, PhD
Associate Professor of Pediatric Immunology (in Pediatrics)
Department of Pediatrics
Program: Tumor Biology and Microenvironment (TBM)
Santiago Correa, PhD
Assistant Professor of Biomedical Engineering
Department of Biomedical Engineering
Program: Tumor Biology and Microenvironment (TBM)
Title: An injectable hydrogel platform for inducing tertiary lymphoid structures in vivo
Description:
In this talk, we will describe our development of a modular hydrogel platform designed to induce tertiary lymphoid structures (TLSs) in vivo. We will highlight our recent work demonstrating the formation of TLS-like immune tissues in healthy murine models, including the emergence of organized B and T cell zones and markers of immune function. We will also discuss our ongoing efforts to apply this platform in cancer models to reprogram the tumor microenvironment and enhance antitumor immunity. Finally, we will share preliminary results using ex vivo human tonsil tissue as a screening system to optimize hydrogel formulations for TLS induction in human-relevant settings.
Join Zoom Meeting
https://columbiacuimc.zoom.us/j/98062087107?pwd=ODN1TFwbtR23dO0Pk7Bq73td7fG91L.1
Meeting ID: 980 6208 7107
Passcode: 267022
