Abdullah Ali, PhD
Assistant Professor of Medical Sciences
Department of Medicine
Program: Precision Oncology and Systems Biology (POSB)
Title: "Tumor macrophage hybrids: a novel source of tumor heterogeneity and metastasis"
Description:
Metastatic cancer remains a leading cause of death globally, and circulating tumor macrophage hybrid (TMH) cells are increasingly implicated in metastatic spread. Despite this, understanding their tissue origins remains limited. To address this gap, we developed a computational framework for identifying TMHs within large single-cell and spatial transcriptomics datasets. Application of this framework to tumor biopsies from patients with colon, breast, and lung cancer revealed the presence of TMHs, elucidated their differential functions, and identified pathways potentially driving their invasive capabilities. These findings highlight TMHs as promising novel therapeutic targets for combating metastatic disease.
Join Zoom Meeting
https://columbiacuimc.zoom.us/j/98062087107?pwd=ODN1TFwbtR23dO0Pk7Bq73td7fG91L.1
Meeting ID: 980 6208 7107
Passcode: 267022
