The Herbert and Florence Irving Institute for Cancer Dynamics will continue its seminar series on the topic of mathematical sciences underpinning cancer research during the 2022-2023 academic year. The monthly seminars take place on the third Wednesday of the month, 2:00-3:00 PM EST. The presentations are open to the Columbia community (in person and online) and to researchers outside Columbia (via Zoom).
On Wednesday, April 19th (2:00 PM ET), IICD welcomes John Marioni, PhD, Senior Vice President and Head of Computation at
Genentech Research and Early Development. Seminar hosted by Simon Tavaré, FRS. The seminar will take place in person in Schermerhorn Hall 603 (Morningside Heights campus). If you wish to attend the seminar remotely, please register using the following link: https://columbiauniversity.zoom.us/meeting/register/tJModeGvqjgoHNHHj0z7NJdL569EWfrsJUke
Title: Computational Challenges in Single-Cell Genomics
Abstract: Over the past decade, technological advances have allowed us to probe multiple molecular characteristics of individual cells. This has enabled the identification of novel cell types and provided an avenue for studying mechanisms in the context of both development and disease. In this presentation, I will discuss some of the computational tools we have developed to address these questions, including approaches for testing for differential abundance and differential expression between conditions that do not rely on pre-defined clusters. I will illustrate these approaches in a variety of contexts, focusing particularly on early embryonic development where the small number of cells in the embryo is particularly well suited to single-cell techniques.
Speaker Bio: John Marioni is the Senior Vice President and Head of Computation at Genentech Research and Early Development (gRED) in South San Francisco. Previously, he was Head of Research at the EMBL-EBI and a Senior Group Leader at the CRUK Cambridge Institute within the University of Cambridge. John read for his PhD under the supervision of Simon Tavaré before working as a postdoc under the supervision of Matthew Stephens. He is a member of EMBO and a Fellow of the United Kingdom's Academy of Medical Sciences.
If you would like to meet one-on-one (possibility via zoom) or attend the lunch or dinner with the speaker, please contact the event organizer.
