The Herbert and Florence Irving Institute for Cancer Dynamics will continue its seminar series on the topic of mathematical sciences underpinning cancer research during the 2022-2023 academic year. The monthly seminars take place on the third Wednesday of the month, 2:00-3:00 PM EST. The presentations are open to the Columbia community (in person and online) and to researchers outside Columbia (via Zoom).
Abstract: Virtually all biological processes are orchestrated by specific interactions between proteins and other molecules. However, these interactions can vary across populations and are altered in diseases such as cancer. In this talk, I will discuss some of the computational methods my group has developed to predict the impact of sequence variation on molecular interactions, with a focus on discovering cancer-relevant proteins and mutations. I will discuss both coding and non-coding mutations in cancer, and touch upon equitable method development in precision oncology.
Bio: Mona Singh is the Wang Family Professor in Computer Science at Princeton University. She has been on the faculty at Princeton since 1999, and is jointly appointed in the Computer Science department and the Lewis-Sigler Institute for Integrative Genomics. Mona obtained her AB and SM degrees at Harvard University, and her PhD at MIT, all three in Computer Science. She did postdoctoral work at the Whitehead Institute for Biomedical Research. She received the Presidential Early Career Award for Scientists and Engineers (PECASE) in 2001, and is a Fellow of the International Society for Computational Biology and a Fellow of the Association for Computing Machinery. She is Editor-In-Chief of the Journal of Computational Biology. She has been program committee chair for several major computational biology conferences, including ISMB (2010), WABI (2010), ACM-BCB (2012), and RECOMB (2016). She has been Chair of the NIH Modeling and Analysis of Biological Systems Study Section (2012-2014), is a council member of the Computing Community Consortium, and is on the steering committee for WABI.