The Herbert and Florence Irving Institute for Cancer Dynamics will continue its seminar series on the topic of mathematical sciences underpinning cancer research during the 2022-2023 academic year. The monthly seminars take place on the third Wednesday of the month, 2:00-3:00 PM EST. The presentations are open to the Columbia community (in person and online) and to researchers outside Columbia (via Zoom).
On Wednesday, January 18th (2:00 PM ET), IICD welcomes Sai Ma, PhD, Assistant Professor Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai. Seminar hosted by Elham Azizi, PhD. The seminar will take place in person in Schermerhorn Hall 603 (Morningside Heights campus). If you wish to attend the seminar remotely, please register using the following link: https://columbiauniversity.zoom.us/meeting/register/tJckf-CupzMjGNKRhHnNrXkAFU8vhuOT4bju
Title: What Drives Cell Fate? A Deep Dive into Epigenomics
Abstract: A stem cell needs to make a series of fate decisions when committing to one cellular lineage over another. Cell fate is regulated by the interplay of multiple epigenomic layers — the collection of molecular and structural modifications on top of the genome — such as chromatin accessibility. Investigation and prediction of cell fate decisions would yield comprehensive insights into the epigenomic rules governing genome function, which ultimately opens up new diagnostic and therapeutic opportunities for human diseases. In this talk, I will present a few recently developed single-cell technologies, including SHARE-seqV2, and their associated computational approaches to gain insights into gene regulation.
Speaker Biography: Dr. Sai Ma is an Assistant Professor of Genetics and Genomic Sciences, a member of Icahn Genomics Institute, a member of the Skin Biology and Diseases Resource-based Center at Mount Sinai (SBDRC), and an affiliate member of the New York Genome Center (NYGC). Sai earned his Bachelor’s degree in Chemistry from Chu Kochen Honors College at Zhejiang University. He then moved to the US and earned his Ph.D. in Biomedical Engineering from a joint program between Virginia Tech and Wake Forest University. Mentored by Dr. Chang Lu, Sai developed microfluidics-based assays for mapping epigenomes in a tiny amount of primary tissues. He received his postdoctoral training from Aviv Regev and Jason Buenrostro at Broad Institute and Harvard Department of Stem Cell and Regenerative Biology (HSCRB). His laboratory primarily focuses on innovating experimental and computational tools to investigate epigenetic mechanisms of gene regulation in single-cells across dynamic cell fate transitions. By integrating approaches across molecular biology, microfluidics, imaging, engineering, and bioinformatics, Sai seeks to elucidate the regulatory diversity of single cells within diverse healthy and diseased tissues, including skin differentiation, hematopoiesis, autoimmune diseases, and tumor progression.