On Monday, October 7th (2:00 PM ET), the Herbert and Florence Irving Institute for Cancer Dynamics welcomes Adam MacLean, Assistant Professor, Department of Quantitative and Computational Biology, University of Southern California. Seminar hosted by Simon Tavaré. The seminar will take place in person in Schermerhorn Hall 603 (Morningside Heights campus). If you wish to attend the seminar remotely, please register using the following link: https://columbiauniversity.zoom.us/meeting/register/tJcpdeGvqTkpGNw2NfzhKhuaUD7gsRCDzJQg
Title: Inferring Cell Fate Networks that Control Outcomes in Complex Tumor-Immune Microenvironments
Abstract: Cell fate decision-making underlies development and homeostasis, and goes awry in cancer. Despite great promise, we have yet to harness the high-resolution information on cell states and fates that single-cell genomics data offer to understand cell fate decisions. Nor do we know in most cases how these decisions are controlled by gene regulatory networks. I will describe our recent work in constructing models of cell fate networks via the multiscale coupling of networks at two levels: cell-cell communication and of gene regulatory states. Through analysis of combination therapies for metastatic breast cancer, we have discovered new mechanisms by which modulation of the tumor-immune microenvironment can improve patient outcomes.
Bio: Adam MacLean develops theory to understand cell fate decision-making in stem cells and cancer. He has developed models of cell-cell communication, and the gene regulatory networks that control cell fate decisions via single-cell multi-omics data analysis and statistical inference. He is an Assistant Professor in the Department of Quantitative and Computational Biology, at the University of Southern California. He studied mathematical physics (BSc) at the University of Edinburgh, and completed a PhD in systems biology from Imperial College London. He worked as a postdoc at the University of Oxford and the University of California Irvine, before joining USC in 2019. Recent awards for his work include an NSF CAREER award (2022) and an NIH R35 MIRA award (2022).
If you would like to meet one-on-one (possibility via zoom) or attend the lunch or dinner with the speaker, please contact the event organizer.
