Dr. Andrew Yates, IICD Associate Member and Professor of Pathology and Cell Biology, recently received an R01 grant from the NIH (second competitive renewal) titled “Modeling the development, structure and regulation of T cell memory”. In this project, they are combining dynamic models, dedicated experimental tools, and novel approaches to inference to study the ecology of CD4 and CD8 T cell memory subsets in mice. Their aims are to quantify how these populations develop in response to environmental or infectious drivers; how they self-renew, compete, wane, and shift in phenotype over time; to identify the rules of replacement of old memory with new; and to disentangle the effects of host age and cell age on memory T cell dynamics.
