Dr. Andrew Yates, IICD Associate Member and Professor of Pathology and Cell Biology, recently received a R01 grant from the NIH (second competitive renewal) titled “Modeling the development, structure and regulation of T cell memory”. In this project, they are combining dynamic models, dedicated experimental tools, and novel approaches to inference to study the ecology of CD4 and CD8 T cell memory subsets in mice. Their aims are to quantify how these populations develop in response to environmental or infectious drivers; how they self-renew, compete, wane, and shift in phenotype over time; to identify the rules of replacement of old memory with new; and to disentangle the effects of host age and cell age on memory T cell dynamics.
