Congratulations to IICD associate faculty member Brent Stockwell, William R. Kenan, Jr. Professor of Biological Sciences, Chemistry, and Pathology & Cell Biology, who was awarded a P01 grant from the National Cancer Institute in collaboration with Xuejun Jiang (Memorial Sloan Kettering Cancer Center) and Wei Gu (Columbia university Irving Medical Center).
The grant will support three key research projects: “Phospholipid remodeling in ferroptosis and cancer” (Leader: Xuejun Jiang), “Targeting specific lipid species that drive ferroptosis resistance” (Leader: Brent Stockwell), “PHLDA2–mediated phospholipid oxidation in ferroptosis and tumor suppression” (Leader: Wei Gu).
Dr. Stockwell will also lead a Shared Resource Core, which will perform lipidomic and ferroptosis biomarkers analysis in cellular models and in vivo models to support all three projects. Together, these efforts aim to explore how cancers modulate ferroptosis (a form of cell death) through lipid metabolism, with the goal of developing new cancer therapeutic strategies for treating aggressive malignancies.
In addition to this grant, Dr. Stockwell was recently recognized among the top 2% of scientists by Stanford and Elsevier, and was ranked among the top 50 scientists in the world across all scientific fields, highlighting his long-lasting impact in cancer biology.
