IICD Newsletter February 2025

February 03, 2025
IICD Newsletter February 3, 2025  🔬
February 3, 2025
 

Faces of IICD: Ben Wesley, Graduate Student

Ben Wesley headshot

Ben Wesley is a fifth-year doctoral student in Drs. Jellert Gaublomme and Simon Tavaré’s labs. He explores ways to leverage single-cell sequencing to understand how genomic perturbances affect the transcriptome. In the latest “Faces of IICD” blog series, Ben shares how his lifelong fascination with mechanics has shaped his unique perspective on research.

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Study Unveils Key Immune Cells Found to Boost Cancer Treatment Success in Acute Myeloid Leukemia

This image highlights key findings from the analysis. It represents a responder's pre-treatment sample, showcasing a variety of cell types, indicated by the diverse array of colored dots.

A research team from Columbia Engineering and the Irving Institute for Cancer Dynamics made a pivotal discovery in the field of cancer immunotherapy. In a paper published today in Science Immunology, the team identified a specific population of immune cells that play a critical role in successful treatment of relapsed acute myeloid leukemia.

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New Study Uncovers How Gliomas Disrupt Brain Function and Points to Rapid Therapeutic Reversal

A new study led by Dr. Peter Canoll’s lab, in collaboration with researchers at Columbia University Irving Medical Center, Columbia’s Zuckerman Institute, and Irving Institute for Cancer Dynamics, along with multiple other researchers at other universities, provides novel insights into how gliomas—aggressive brain tumors—cause debilitating neurological symptoms such as seizures and cognitive impairments. 

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IICD Seminar Series: December Seminar


Quantitative Approaches to Understanding Cell Evolution and Treatment Response

Hosted by: Franziska Michor, PhD
Date: February 12th, 2025 
Time: 2:00 PM (ET)
Location: Online

 
Register Here

IICD Highlights

Samuel Aparicio and Marc J. Williams
A recent research briefing by Samuel Aparicio and Marc J. Williams discusses their latest work exploring the spatial genomic heterogeneity of breast cancer, providing new insights into the genetic evolution of tumors within their microenvironment.  Read here


 
Elham Azizi headshot
IICD Core Faculty Member Elham Azizi has been promoted to the rank of Associate Professor. Her work aims to characterize the complex populations of interacting cell types in the tumor microenvironment and their underlying circuitry by leveraging cutting-edge single-cell genomic technologies.

 
Headshot of Neeha
We are thrilled to welcome Neeharika Kothapalli ("Neeha")to the IICD community! She is MD-PhD student, with a focus on developing computational tools to address complex questions in genomics and cancer biology under the guidance of Profs. Azizi and Izar.

 

Recent Publications from IICD Researchers

Adaptive Nonparametric Perturbations of Parametric Bayesian Models. Wu, B.; Weinstein, E. N.; Salehi, S.; Wang, Y.; Blei, D. M. arXiv 2024

Automated Cell Type Annotation with Reference Cluster Mapping. Galanti, V.; Shi, L.; Azizi, E.; Liu, Y.; Blumberg, A. J. bioRxiv 2024.

Characterizing the Evolutionary Dynamics of Cancer Proliferation in Single-Cell Clones with SPRINTER. Lucas, O.; Ward, S.; Zaidi, R.; Bunkum, A.; Frankell, A. M.; Moore, D. A.; Hill, M. S.; Liu, W. K.; Marinelli, D.; Lim, E. L.; Hessey, S.; Naceur-Lombardelli, C.; Rowan, A.; Purewal-Mann, S. K.; Zhai, H.; Dietzen, M.; Ding, B.; Royle, G.; Aparicio, S.; McGranahan, N.; Jamal-Hanjani, M.; TRACERx Consortium; PEACE Consortium; Kanu, N.; Swanton, C.; Zaccaria, S. Nature Genetics 2024, in press.
 

Coordinated Immune Networks in Leukemia Bone Marrow Microenvironments Distinguish Response to Cellular Therapy. Maurer, K.; Park, C. Y.; Mani, S.; Borji, M.; Raths, F.; Gouin, K. H.; Penter, L.; Jin, Y.; Zhang, J. Y.; Shin, C.; Brenner, J. R.; Southard, J.; Krishna, S.; Lu, W.; Lyu, H.; Abbondanza, D.; Mangum, C.; Olsen, L. R.; Lawson, M. J.; Fabani, M.; Neuberg, D. S.; Bachireddy, P.; Glezer, E. N.; Farhi, S. L.; Li, S.; Livak, K. J.; Ritz, J.; Soiffer, R. J.; Wu, C. J.; Azizi, E.  Science Immunology 2025, 10 (103), eadr0782.

Echidna: A Bayesian Framework for Quantifying Gene Dosage Effect Impacting Phenotypic Plasticity. Fan, J. L.; Zhang, M.; O'Brien, W. G.; Myers, J. D.; Melms, J. C.; Biermann, J.; D'Souza, E.; Tagore, S.; Beltran-Velez, N.; Hoffer-Hawlik, K.; Preau, A.; Arora, I.; Chatterjee, S.; Izar, B.; Azizi, E. bioRxiv 2024.

Ferroptosis—Disease Perils and Therapeutic Promise. Brown, A. R.; Hirschhorn, T.; Stockwell, B. R. Science 2024, 386 (6724), 848-849.

Glioma-Induced Alterations in Excitatory Neurons are Reversed by mTOR Inhibition. Goldberg, A. R.; Dovas, A.; Torres, D.; Pereira, B.; Viswanathan, A.; Das Sharma, S.; Mela, A.; Merricks, E. M.; Megino-Luque, C.; McInvale, J. J.; Olabarria, M.; Shokooh, L. A.; Zhao, H. T.; Chen, C.; Kotidis, C.; Calvaresi, P.; Banu, M. A.; Razavilar, A.; Sudhakar, T. D.; Saxena, A.; Chokran, C.; Humala, N.; Mahajan, A.; Xu, W.; Metz, J. B.; Bushong, E. A.; Boassa, D.; Ellisman, M. H.; Hillman, E. M. C.; Hargus, G.; Bravo-Cordero, J. J.; McKhann, G. M.; Gill, B. J. A.; Rosenfeld, S. S.; Schevon, C. A.; Bruce, J. N.; Sims, P. A.; Peterka, D. S.; Canoll, P. Neuron 2025.

Interpretable Neural ODEs for Gene Regulatory Network Discovery under Perturbations. Lin, Z.; Chang, S.; Zweig, A.; Azizi, E.; Knowles, D. A. arXiv 2025

Luminal Breast Epithelial Cells of BRCA1 or BRCA2 Mutation Carriers and Noncarriers Harbor Common Breast Cancer Copy Number Alterations. Williams, M. J.; Oliphant, M. U. J.; Au, V.; Liu, C.; Baril, C.; O’Flanagan, C.; Lai, D.; Beatty, S.; Van Vliet, M.; Yiu, J. C. H.; O’Connor, L.; Goh, W. L.; Pollaci, A.; Weiner, A. C.; Grewal, D.; McPherson, A.; Norton, K.; Moore, M.; Prabhakar, V.; Agarwal, S.; Garber, J. E.; Dillon, D. A.; Shah, S. P.; Brugge, J. S.; Aparicio, S. Nature Genetics 2024, in press.

Posterior Mean Matching: Generative Modeling through Online Bayesian Inference. Salazar, S.; Kucer, M.; Wang, Y.; Casleton, E.; Blei, D. arXiv 2024

Subsampling, Aligning, and Averaging to Find Circular Coordinates in Recurrent Time Series. Blumberg, A. J.; Carrière, M.; Fung, J. H.; Mandell, M. A. arXiv 2024

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