Notes from the Lab: a Framework for Modeling Cancer Evolution in Single Cell

April 28, 2023

Dr. Khanh Dinh (Simon Tavaré's group) developed a mathematical model to track tumor development over time. When applied to general DNA-seq data, the model maps the DNA change patterns across the cancer genome to quantitative scores for individual chromosomes. These scores have shown remarkable agreement with different gene types located on these chromosomes, therefore proving the model’s biological relevance.

Read the story in "Notes from the Lab", a series by the Herbert Irving Comprehensive Center which spotlights innovative work addressing problems in cancer research and care from Columbia investigators, post-docs, fellows, and students: https://www.cancer.columbia.edu/news/framework-modeling-cancer-evolution-single-cells