IICD Newsletter August 2025

August 04, 2025
Stay Informed: IICD August 2025 News and Events 🔬
August 4, 2025
 

From Paris to Columbia: A Q&A with Alliance Interns

Léandre Simon, Sara El Baghdadi, and Ethan Cohen

As the 2025 Alliance Program wraps up, we caught up with three of our visiting master’s students from École Polytechnique—Léandre Simon, Sara El Baghdadi, and Ethan Cohen—who spent four months conducting cancer research at IICD. From modeling stem cell behavior to simulating tumor evolution, their projects bridged the gap between applied mathematics and biology in exciting ways.

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IICD Seminar Series 2025–2026

We’re thrilled to announce our 2025–2026 IICD Seminar Series lineup, featuring trailblazing researchers in cancer genomics, computational biology, and the mathematical sciences.⁠ Speakers this year hail from Stanford, MIT, MD Anderson, Harvard, Human Technopole, and more. View the full lineup and learn how to attend.

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IICD Highlights

Welcome to Our New IICD Members

Tina Giorgadze and William Milligan
We’re thrilled to welcome two new members to the IICD community:
  • Tina Giorgadze, PhD student in the Tavaré Lab
  • William Milligan, Postdoctoral Researcher in IICD
We’re excited to have them on board and look forward to the contributions they’ll bring to our dynamic community.
Lela Devine pointing to her poster.
Congratulations to Lela DeVine (Stockwell Lab) on receiving an IICD Travel Award to attend the BEACON 2025 Astrobiology Conference held July 1–5 in Reykjavik, Iceland. Lela is a recent graduate from Barnard College with a degree in Molecular Biology.

 
Yining Liu headshot
Congratulations to Dr. Yining Liu on her new role as Lecturer in Data Science in Columbia’s Department of Computer Science. Yining recently completed her PhD under the mentorship of IICD members Andrew Blumberg and Itsik Pe’er. Keep in touch with Yining here

 
Apoorva Singh headshot
Congratulations to Dr. Apoorva Singh, Postdoctoral Research Scientist, on being selected for an AAI Travel Grant. This award supported her attendance at the 2025 Introductory Course in Immunology, held from July 8 to 13 in Los Angeles. The course offers a valuable foundation for early-career scientists in the field.
 
Tarek Zikry headshot
We are excited to congratulate Dr. Tarek Zikry, former postdoc in Genevera Allen’s group, on his new position as Assistant Professor at UNC-Chapel Hill, School of Data Science and Society. We wish him continued success as he embarks on this exciting new chapter! Keep in touch with Tarek here!

Recent Publications from IICD Researchers

Accelerating Biomedical Discoveries in Brain Health through Transformative Neuropathology of Aging and Neurodegeneration. Murray, M. E.; Smith, C.; Menon, V.; Keene, C. D.; Lein, E.; Hawrylycz, M.; Aguzzi, A.; Benedetti, B.; Brose, K.; Caetano-Anolles, K.; Sillero, M. I. C.; Crary, J. F.; De Jager, P. L.; Faustin, A.; Flanagan, M. E.; Gokce, O.; Grant, S. G. N.; Grinberg, L. T.; Gutman, D. A.; Hillman, E. M. C.; Huang, Z.; Irwin, D. J.; Jones, D. T.; Kapasi, A.; Karch, C. M.; Kukull, W. T.; Lashley, T.; Lee, E. B.; Lehner, T.; Parkkinen, L.; Pedersen, M.; Pritchett, D.; Rutledge, M. H.; Schneider, J. A.; Seeley, W. W.; Shepherd, C. E.; Spires-Jones, T. L.; Steen, J. A.; Sutherland, M.; Vickovic, S.; Zhang, B.; Stewart, D. J.; Keiser, M. J.; Vogel, J. W.; Dugger, B. N.; Phatnani, H. Neuron. 2025, in press.

A Linear Ontogeny Accounts for the Development of Naive, Memory, and Tumor-Infiltrating Regulatory T Cells in Mice. Pathak, S.; Hogan, T.; Rane, S.; Huang, Y.; Pearson, C.; Sinclair, C.; Barry, S.; Carnevalli, L.; Yates, A. J.; Seddon, B. Science immunology 2025, 10(108), eadu7341.

Anomaly Detection in Spatial Transcriptomics via Spatially Localized Density Comparison. Hu, G.; Gold, J.; Chitra, U.; Joshi, S.; Raphael, B. J. Bioinformatics 2025, 41, i493-i501.

CN-SBM: Categorical Block Modelling for Primary and Residual Copy Number Variation. Lam, K.; Daniels, W.; Douglas, J. M.; Lai, D.; Aparicio, S.; Bloem-Reddy, B.; Park, Y.  arXiv 2025.

Genomic Alterations in the YAP/TAZ Pathway are Associated with Stem Cell-Like Castration-Resistant Prostate Cancer. Roskes, M. L.; Martinez-Fundichely, A.; Cohen, S.; Balaban, M.; Wong, C. K.; Li, W.; Gonzalez, T. A.; Tehim, A. B.; Xu, H.; ElNaggar, S.; Myers, M.; Bareja, R.; Dorsaint, P.; Gorski, K.; Asad, M.; Assaad, M. A.; Robinson, B. D.; Sigouros, M.; Barnett, E.; Manohar, J.; Tagawa, S.; Nanus, D.; Molina, A.; Nauseef, J. T.; Sternberg, C. N.; Mosquera, J. M.; Scher, H. I.; Sboner, A.; Raphael, B. J.; Chen, Y.; Khurana, E. medRxiv 2025.

Joint Representation and Visualization of Derailed Cell States with Decipher. Nazaret, A.; Fan, J. L.; Lavallée, V.-P.; Burdziak, C.; Cornish, A. E.; Kiseliovas, V.; Bowman, R. L.; Masilionis, I.; Chun, J.; Eisman, S. E.; Wang, J.; Hong, J.; Shi, L.; Levine, R. L.; Mazutis, L.; Blei, D.; Pe’er, D.; Azizi, E. Genome Biology 2025, 26 (1), 219.

Maximum Likelihood Inference of Time-Scaled Cell Lineage Trees with Mixed-Type Missing Data using LAML. Chu, G.; Mai, U.; Schmidt, H.; Raphael, B. J. Genome Biology 2025, 26 (1), 189.

Ongoing Genome Doubling Shapes Evolvability and Immunity in Ovarian Cancer. McPherson, A.; Vázquez-García, I.; Myers, M. A.; Al-Rawi, D. H.; Zatzman, M.; Weiner, A. C.; Freeman, S.; Mohibullah, N.; Satas, G.; Williams, M. J.; Ceglia, N.; Norkūnaitė, D.; Zhang, A. W.; Li, J.; Lim, J. L. P.; Wu, M.; Choi, S.; Havasov, E.; Grewal, D.; Shi, H.; Kim, M.; Schwarz, R. F.; Kaufmann, T.; Dinh, K. N.; Uhlitz, F.; Tran, J.; Wu, Y.; Patel, R.; Ramakrishnan, S.; Kim, D.; Clarke, J.; Green, H.; Ali, E.; DiBona, M.; Varice, N.; Kundra, R.; Broach, V.; Gardner, G. J.; Roche, K. L.; Sonoda, Y.; Zivanovic, O.; Kim, S. H.; Grisham, R. N.; Liu, Y. L.; Viale, A.; Rusk, N.; Lakhman, Y.; Ellenson, L. H.; Tavaré, S.; Aparicio, S.; Chi, D. S.; Aghajanian, C.; Abu-Rustum, N. R.; Friedman, C. F.; Zamarin, D.; Weigelt, B.; Bakhoum, S. F.; Shah, S. P. Nature 2025, in press.

Stochastic Dynamics of Two-Compartment Cell Proliferation Models with Regulatory Mechanisms for Hematopoiesis. Wang, R. Y.; Kimmel, M.; Pang, G. J. Math. Biol. 2025, 91, 18.

The Somatic Mosaicism across Human Tissues Network. Coorens, T. H. H.; Oh, J. W.; Choi, Y. A.; Lim, N. S.; Zhao, B.;  Voshall, A.; Abyzov, A.; Antonacci-Fulton, L.; Aparicio, S.; Ardlie, K. G.; Bell, T. J.; Bennett, J. T.; Bernstein, B. E.; Blanchard, T. G.; Boyle, A. P.; Buenrostro, J. D.; Burns, K. H.; Chen, F.; Chen, R.; Choudhury, S.; Doddapaneni, H. V.; Eichler, E. E.; Evrony, G. D.; Faith, M. A.; Fazzio, T. G.; Fulton, R. S.; Garber, M.; Gehlenborg, N.; Germer, S.;Getz, G.; Gibbs, R. A.;  Hernandez, R. G.; Jin, F.; Korbel, J. O.; Landau, D. A.; Lawson, H. A.; Lennon, N. J.; Li, H.; Li, Y.; Loh, P.-R.; Marth, G.; McConnell, M. J.; Mills, R. E.; Montgomery, S. B.; Natarajan, P.; Park, P. J.; Satija, R.; Sedlazeck, F. J.; Shao, D. D.; Shen, H.; Stergachis, A. B.; Underhill, H. R.; Urban, A. E.;  VonDran, M. W.; Walsh, C. A.; Wang, T.; Wu, T. P.; Zong, C.; Lee, E. A.; Vaccarino, F. M. Nature 2025, 643 (8070), 47-59.

Variational Learning of Disentangled Representations. Slavutsky, Y.; Beker, O.; Blei, D.; Dumitrascu, B. arXiv 2025.

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