Approximate Bayesian Computation and Distributional Random Forests
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Khanh Dinh, Simon Tavaré, and Zijin Xiang explain the evolution of statistical inference for stochastic processes, presenting ABC-DRF as a solution to longstanding challenges. Distributional random forests, introduced in Cevid et al. (2022), revolutionize regression problems with multi-dimensional dependent variables, and also offer a promising avenue for Bayesian inference. Don't miss the detailed illustration of ABC-DRF methods applied to a compelling toy model, showcasing its potential to reshape the landscape of ABC.
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IICD Launches New LinkedIn Page
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Exciting updates, IICD community! We're thrilled to launch our official LinkedIn page. Join us as we expand our online presence and share valuable insights, news, and opportunities within the Irving Institute for Cancer Dynamics community. Follow us on LinkedIn, X, Instagram, and YouTube to stay in the loop with all things IICD!
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IICD Seminar Series: March Seminar
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The IICD continues its monthly seminar series on the topic of mathematical sciences underpinning cancer research. Join us for an enlightening session with Brittany Adamson, Assistant Professor of Molecular Biology and Lewis-Sigler Institute for Integrative Genomics at Princeton University. Seminar hosted by José McFaline-Figueroa.
Date: March 13th, 2024
Time: 2:00 PM (ET)
Location: Fairchild 700 and Online
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Thomas Cong, a high school student working in IICD affiliate member David Tourigny’s lab, was selected as a finalist in the 2024 Regeneron Science Talent Search. Finalists were selected from 300 scholars and 2,162 entrants, the largest pool of applicants since the 1960s. Read more.
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Joy Fan, a PhD student in biomedical engineering, was selected as a recipient of the Avanessians Fellowship for the 2024 Spring semester. Every year, the Fellowship supports fellows across Engineering disciplines whose research focuses on or intersects with data science. Read more.
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Ben Raphael was named an ACM fellow. The Association for Computing Machinery fellows represent the top 1% of ACM members and are selected by their peers for transformative contributions to computing science and technology. Raphael is one of 68 fellows recognized this year. Read more.
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In a recent Cell publication, IICD member Brent Stockwell and his group found that a rare type of lipid is a key driver of ferroptosis. The findings provide new detail on how cells die during ferroptosis and could improve understanding of how to stop ferroptosis in contexts where it is harmfully occurring. Read more.
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Ignacio Vazquez-Garcia was selected for the 2024 AACR NextGen Stars Program. This accolade recognizes his pioneering research on cellular dynamics in cancer. His work has helped identify the role of genomic instability in cancer evolution and its impact on the tumor microenvironment. Read more.
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2024 NCI Spring School on Algorithmic Cancer Biology
(April 1-5th, 2024)
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Advances in tumor sequencing have resulted in large scale genomic, transcriptomic and epigenomic datasets. The analysis of these datasets has led to several new discoveries in cancer. For this reason, many cancer research institutions in the private sector, government and academia now have groups of computer scientists, genomicists, mathematicians, statisticians, engineers and physicists to develop algorithmic methods to analyze these datasets. SSACB aims to increase these interactions by bringing together a small group of participants with diverse backgrounds and expertise.
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Recent Publications from IICD Researchers
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A Deep Learning Framework for Predicting Patient Decannulation on Extracorporeal Membrane Oxygenation Devices: Development and Model Analysis Study. Fuller, J.; Abramov, A.; Mullin, D.; Beck, J.; Lemaitre, P.; Azizi, E. JMIR Biomed Eng 2024, 9, e48497.
Coordinated Immune Cell Networks in the Bone Marrow Microenvironment Define the Graft versus Leukemia Response with Adoptive Cellular Therapy. Maurer, K.; Park, C. Y.; Mani, S.; Borji, M.; Penter, L.; Jin, Y.; Zhang, J. Y.; Shin, C.; Brenner, J. R.; Southard, J.; Krishna, S.; Lu, W.; Lyu, H.; Abbondanza, D.; Mangum, C.; Olsen, L. R.; Neuberg, D. S.; Bachireddy, P.; Farhi, S. L.; Li, S.; Livak, K. J.;Ritz, J.; Soiffer, R. J.; Wu, C. J.; Azizi, E. bioRxiv 2024.
Human Vascular Organoids with a Mosaic AKT1 Mutation Recapitulate Proteus Syndrome. He, S.; Zhu, Y.; Chauhan, S.; Tavakol, D. N.; Lee, J. H.; Berris, R. B.-L.; Xu, C.; Lee, J. H.; Lee, C.; Cai, S.; McElroy, S.; Vunjak-Novakovic, G.; Tomer, R.; Azizi, E.; Xu, B.; Lao, Y.-H.; Leong, K. W. bioRxiv 2024.
MarkerMap: Nonlinear Marker Selection for Single-Cell Studies. Gregory, W.; Sarwar, N.; Kevrekidis, G.; Villar, S.; Dumitrascu, B. npj Systems Biology and Applications 2024, 10 (1), 17.
Measures Determined by their Values on Balls and Gromov-Wasserstein Convergence. Van Delf, A.; Blumberg, A. J. arXiv 2024.
Multimodal Mass Spectrometry Imaging Identifies Cell-Type-Specific Metabolic and Lipidomic Variation in the Mammalian Liver. Tian, H.; Rajbhandari, P.; Tarolli, J.; Decker, A. M.; Neelakantan, T. V.; Angerer, T.; Zandkarimi, F.; Remotti, H.; Frache, G.; Winograd, N.; Stockwell, B. R. Developmental Cell 2024, in press.
Order-of-Mutation Effects on Cancer Progression: Models for Myeloproliferative Neoplasm. Wang, Y.; Shtylla, B.; Chou, T. Bull Math Biol 2024, 86 (3), 32.
Phospholipids with Two Polyunsaturated Fatty Acyl Tails Promote Ferroptosis. Qiu, B.; Zandkarimi, F.; Bezjian, C. T.; Reznik, E.; Soni, R. K.; Gu, W.; Jiang, X.; Stockwell, B. R. Cell 2024, in press.
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