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The IICD Joins Velocity: Columbia's Ride to End Cancer Once Again
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In its third consecutive year, the IICD takes on the challenge of supporting Velocity: Columbia's Ride to End Cancer. So far, the team has raised over $2,100 to support life-saving research and comprehensive care for patients and their families at the Herbert Irving Comprehensive Cancer Center.
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Next Speaker in the IICD Seminar Series
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Computational Methods for Inferring Tumor Evolution and Heterogeneity
Hosted by Simon Tavaré, FRS
Date: October 11, 2023
at 2 PM (ET)
Location: Fairchild 700 and online
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 Congratulations to Sanket Rane who was awarded an R01 grant from the National Institutes of Health for an innovative integrative project that synthesizes mathematical and experimental strategies to generate a quantitative understanding of marginal zone (MZ) B cell ontogeny, maintenance, and response to antigenic challenges across the lifespan. Read more.
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 Congratulations to IICD Faculty Elham Azizi (Department of Biomedical Engineering) who was awarded an R21 grant from the National Institutes of Health to develop a computational toolbox for characterizing the spatial dynamics of diverse cell types in complex tissues using spatial transcriptomics data. Read more.
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 Congratulations to Presha Rajbhandari (Stockwell lab) who received the newly-established Charles H. Turner Award for Postdoctoral Studies in Biological Sciences for her work on developing a multi-modal imaging pipeline to identify the cellular and metabolic composition of mouse and human livers, down to single cell resolution. Read more.
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 Anabel Ojeda was recently featured in Adelphi University’s news. Anabel shared about her participation in the IICD SRP and her research experience using technology to further the understanding of the behavior of tumor cells in Elham Azizi’s lab. Read more.
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 Roy Ghosh is a PhD student in the department of Biomedical Engineering who recently joined Sanja Vicković’s lab. Roy is working on optimizing multi-omics technologies and leveraging such tools with the aim of identifying translatable therapeutic targets critical to disease networks. Read more.
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 Ruiyang He is a PhD student in the department of Biomedical Engineering who recently joined Sanja Vicković’s lab. Ruiyang is interested in developing novel computational methods integrated with advances in spatial transcriptomics technologies to dissect the importance of spatial organization in development and disease. Read more.
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11th Integrated Mathematical Oncology (IMO) Workshop
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The IMO workshop is designed to motivate and facilitate a hands-on modeling experience focused on Steering cancer evolution through therapeutic intervention. The workshop is comprised of both an educational event and competition and divides participants into multiple teams combining clinical, experimental, and theoretical members. The event will take place October 29th-November 3rd, 2023.
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Recent Publications from IICD Researchers
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A MYCN-Independent Mechanism Mediating Secretome Reprogramming and Metastasis in MYCN-Amplified Neuroblastoma. Zhang, H. F.; Delaidelli, A.; Javed, S.; Turgu, B.; Morrison, T.; Hughes, C. S.; Yang, X.; Pachva, M.; Lizardo, M. M.; Singh, G.; Hoffmann, J.; Huang, Y. Z.; Patel, K.; Shraim, R.; Kung, S. H. Y.; Morin, G. B.; Aparicio, S.; Martinez, D.; Maris, J. M.; Bosse, K. R.; Williams, K. C.; Sorensen, P. H. Sci Adv 2023, 9 (34), eadg6693.
CellStitch: 3D Cellular Anisotropic Image Segmentation via Optimal Transport. Liu, Y.; Jin, Y.; Azizi, E.; Blumberg, A. J. BioRxiv 2023.
Order-of-Mutation Effects on Cancer Progression: Models for Myeloproliferative Neoplasm. Wang, Y.; Shtylla, B.; Chou, T. MedRxiv 2023.
Probing the Cytotoxic Signaling Induced by Eupenifeldin in Ovarian Cancer Models. Maldonado, A. C.; Haughan, M. A.; Khin, M.; Ekiert, J.; Zhang, Z.; Lantvit, D.; Al Subeh, Z. Y.; Pierre, H. C.; Salkovski, M.; Hirschhorn, T.; Gao, Y.; Pearce, C. J.; Stockwell, B. R.; Aldrich, L. N.; Oberlies, N. H.; Burdette, J. E. J Nat Prod 2023 in press.
p53 Gain-of-Function Mutation Induces Metastasis via Brd4-dependent Csf-1 Expression. Efe, G.; Dunbar, K. J.; Sugiura, K.; Cunningham, K.; Carcamo, S.; Karaiskos, S.; Tang, Q.; Cruz-Acuna, R.; Resnick-Silverman, L.; Peura, J.; Lu, C.; Hasson, D.; Klein-Szanto, A. J.; Taylor, A. M.; Manfredi, J. J.; Prives, C.; Rustgi, A. K. Cancer Discovery 2023, in press.
Site-Specific Development and Progressive Maturation of Human Tissue-Resident Memory T Cells over Infancy and Childhood. Connors, T. J.; Matsumoto, R.; Verma, S.; Szabo, P. A.; Guyer, R.; Gray, J.; Wang, Z.; Thapa, P.; Dogra, P.; Poon, M. M. L.; Rybkina, K.; Bradley, M. C.; Idzikowski, E.; McNichols, J.; Kubota, M.; Pethe, K.; Shen, Y.; Atkinson, M. A.; Brusko, M.; Brusko, T. M.; Yates, A. J.; Sims, P. A.; Farber, D. L. Immunity 2023, 56 (8), 1894-1909 e5.
Supervised Discovery of Interpretable Gene Programs from Single-Cell Data. Kunes, R. Z.; Walle, T.; Land, M.; Nawy, T.; Pe’er, D. Nature Biotechnology 2023, in press.
The CausalBench Challenge: A Machine Learning Contest for Gene Network Inference from Single-Cell Perturbation Data. Chevalley, M.; Sackett-Sanders, J.; Roohani, Y.; Notin, P.; Bakulin, A.; Brzezinski, D.; Deng, K.; Guan, Y.; Hong, J.; Ibrahim, M.; Kotlowski, W.; Kowiel, M.; Misiakos, P.; Nazaret, A.; Püschel, M.; Wendler, C.; Mehrjou, A.; Schwab, P. ArXiv 2023.
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